Bone Cancer Vaccine Without Amputation
Meet Denali:10-year-old Italian Spinoni
Clinical Trial: Bone cancer vaccine now being evaluated for dogs with osteosarcoma without amputation
Learn about eligibility and trial details...
Status: This trial is open and enrolling dogs. There are places for 10 dogs diagnosed with early osteosarcoma on this trial.
About This Trial
This new clinical trial uses a novel vaccine for dogs with bone cancer (osteosarcoma). Dr. Mason, an Assistant Professor of Medicine is evaluating the effect of combining a tumor-targeting vaccine with radiation therapy to treat dogs that cannot undergo amputation.
“In the past we have tested this vaccine to determine whether it can prevent spread of osteosarcoma in dogs that had undergone amputation and chemotherapy (the standard of care for dogs with osteosarcoma). The results were encouraging.
"Now we are evaluating whether the same vaccine can be used to treat the primary tumor as well as prevent spread of the disease into the lungs – that is, we are now treating dogs that cannot undergo amputation and follow up chemotherapy.”
The trial is unique – dogs are required to have a biopsy to confirm the diagnosis of osteosarcoma, they receive 2 doses of radiation on 2 consecutive days and are then vaccinated once every 3 weeks for a total of 8 vaccines. There is no chemotherapy in this clinical protocol.
Read more about Denali and the trial at: https://www.vet.upenn.edu/research/cent ... tion-trial